The updates are as follows:
Appendix 1: Acceptable intakes established for N-nitrosamines
| Nitrosamine | Source | CPCA | AI(ng/day) |
|---|---|---|---|
| N-nitroso-berotralstat | Berotralstat | 2 | 100 |
| N-nitroso-desmethyl-doxylamine | Doxylamine | -(Read across from NNK) | 100 |
| N-nitroso-doravirine dimer | Doravirine | -(Mutagenicity test negative) | 1500 |
| N-nitroso hydroxychloroquine EP Impurity C | Hydroxychloroquine | 2 | 100 |
| N-nitroso hydroxychloroquine EP Impurity D | Hydroxychloroquine | 1 | 18 |
| N-nitroso-hydroxyzine Impurity A | Hydroxyzine | 3 | 400 |
| N-nitroso-methylaminoantipyrine | Metamizole | 2 | 100 |
| N-nitroso-methylethanolamine | Nefopam | 2 | 100 |
| N-nitroso-mirdametinib | Mirdametinib | -(Read across from NDPh) | 78000 |
| N-nitroso-nirogacestat | Nirogacestat | -(Mutagenicity test negative) | 1500 |
| N-nitroso-nirogacestat impurity 1 | Nirogacestat | 5 | 1500 |
| N-nitroso-propafenone impurity B | Propafenon | 2 | 100 |
| N-nitroso venlafaxine EP Impurity D | Venlafaxine | 1 | 18 |
| N-nitroso venlafaxine EP Impurity H | Venlafaxine | 2 | 100 |