🇪🇺 EMA Q&A Rev. 16 EMA/409815/2020 - MAJOR UPDATE

For this structure, I would say:

The hydrogen count is indeed (2,2) for one point

The six-membered ring is not strictly a piperidine, because of the aromatic thiazole fused to it (and the six-membered ring is definitely not aromatic itself, fails Huckel’s rule) - piperidine implies all ring bonds are single. However, the CPCA rule gives two points both to piperidines and to all 6-membered rings other than sulphur-containing and morpolines, so still two points

That fused thiazole, though, means that the a-carbon is activated by being in a benzylic-like position (the first-listed activating feature), for -1 point

Total score: 2

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