Synthesis of Nitroso Derivatives of Dihydropyridine Calcium Channel Blockers

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Don’t forget @conudel already warned us about this family of compounds!!

N-nitroso-amlodipine ; N-nitroso-felodipine ; synthesis not successfull but still listed by FDA and EMA as NDSRIs

Dear Nitrosamines Exchange team, For the nitrosamines N-nitroso-amlodipine and N-nitroso-felodipine, official limits are published by the FDA. FDA Guidance In the past, we contacted several suppliers who offered the N-nitroso-amlodipine on their web pages: However, N-nitroso-amlodipine could not be synthesized in the end. This outcome is confirming the EFPIA position paper. Position Paper (efpia) Does anyone from the community know if the FDA or EMA have been contacted to remove these com…