Synthesis of Nitroso Derivatives of Dihydropyridine Calcium Channel Blockers

[Dileep5571]

@N-nitroso-amlodipine ; N-nitroso-felodipine ; synthesis not successfull but still listed by FDA and EMA as NDSRIs

munity know if the FDA or EMA have been contacted to remove these com…

Hi Naiffer,

We have contacted with scientiifc justification for non formation of N-Nitroso Amlodipine & FDA accepted the approach. However guidance still have these imp[urities.