As far as I’m aware, nitrosamine testing is only included on ad-hoc basis in the scope of E&L studies. This might be the result of a risk assessment of the sponsor, or on own suggestion when we learn the materials of construction. If there would appear a clear framework, guideline or recommendation whether or not to include nitrosamine testing in E&L studies, I would be happy to take notice.
For sure, the low limits for nitrosamines require targeted methods so unfortunately nitrosamines will likely not be detected with the chromatography - mass spectrometry screening methods. But it might be interesting to screen for possible precursors like secondary or tertiary amines in the GC/MS or LC/MS screening analysis. Since these precursors might lead to nitrosamine formation under the appropriate conditions, this might be a trigger for further targeted nitrosamine analysis.
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