U̶p̶c̶o̶m̶i̶n̶g̶ Nitrosamine Special Issue of JPS

[Naiffer_Host]

Solid State Kinetics of Nitrosation Using Native Sources of Nitrite -Pub

Publication " Solid State Kinetics of Nitrosation Using Native Sources of Nitrite" by Carloni et al. Link: https://doi.org/10.1016/j.xphs.2023.02.014 Abstract While many reactive species are known to cause N -nitrosation, trace nitrite (NO2−), which may be present in several excipients, is a source of nitrosating agents in pharmaceutical formulations. In this study we have found that the salt form of NO2− can influence the kinetics and final amount of nitrosamine being formed. Using native l…

UHPLC-APCI-TQ-MS analytical method capable of quantifying eight nitrosamine impurities from five different Metformin Formulations -Pub

Publication: “UHPLC-APCI-TQ-MS analytical method capable of quantifying eight nitrosamine impurities from five different commercially available Metformin formulations with Glipizide, Glibenclamide, Gliclazide, Evogliptin, and Glimepiride” by Solaki et al. Link: https://doi.org/10.1016/j.xphs.2023.02.016 Abstract: Metformin and its combinations are widely used to treat type 2 diabetes. The drugs commonly used in combination with Metformin are Glipizide, Glibenclamide, Gliclazide, Evogliptin, …