Dear all,
we have just published a new study in the journal Processes on the topic of nitrite scavengers for nitrosamine formation prevention.
The title is Assessment of a Diverse Array of Nitrite Scavengers in Solution and Solid State: A Study of Inhibitory Effect on the Formation of Alkyl-Aryl and Dialkyl N-Nitrosamine Derivatives. Processes | Free Full-Text | Assessment of a Diverse Array of Nitrite Scavengers in Solution and Solid State: A Study of Inhibitory Effect on the Formation of Alkyl-Aryl and Dialkyl N-Nitrosamine Derivatives
After an extensive literature evaluation, we have selected 19 potential nitrite scavengers and evaluated them experimentally under pharmaceutically relevant conditions. Six compounds were then chosen for additional tests to evaluate their nitrosamine formation inhibition on two model APIs both in solution and in solid state (tablets). N-methylaniline and 1-phenylpiperazine were chosen as two representative secondary amines.
Ascorbic acid, para-aminobenzoic acid, and cysteine were found to be the most widely useful inhibitors, although there were differences depending on the setup (solution/solid state) and nature of the model amine. We believe our study adds additional insight into a promising strategy for nitrosamine formation mitigation, but emphasizes that the scavenger must be chosen on a case-by-case approach.
Enjoy the read!
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