A substructure-based screening approach to uncover Nnitrosamines in drug substances

New Scientific Knowledge & Development
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Publication by Kao et al

  • A substructure-based screening method employing DataWarrior, an opensource
    software, was established to evaluate the risks of NA impurities in drug substances.
  • method detected 192 drug substances with a theoretical possibility of NA impurity, 141 of which had not been reported previously.

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A substructure-based screening approach to uncover N-nitrosamines.pdf (3.0 MB)

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