Posting on behalf of one of our community members.
Anyone experienced low level interference/ contamination issues with NDBA during method development?
Hello. The answer is yes. NDBA is a nitrosamine present in plastics and rubbers. It is actually an additive. I work with an HR MS and I watch it.
False positives of NDBA can be obtained in processes that subject plastics to high pressures, for example syringes and filters (at the laboratory level)
I personally have not found any lab supply manufacturer that does not have NDBA in any of their plastic materials. I asked if there was glass material but it is not manufactured.
The solution is a bit difficult because the release of NDBA depends on the level of pressure to which the plastic is subjected, so creating a control sample as a blank does not help much.
Agreed. This one does have the tendency to generate false positive. One needs to be careful with the same.