Is there any known NDSRIs for Apixaban? Have you faced any of them in your projects or came across in a publication or a presentation?
If there is no knwon NDSRIs, what is the proper method to identify possible NDSRIs?
Thanks for your usual support.
My advice would be to go through all related substances, both process impurities from the manufacturing process of the API, including intermediates, and degradation impurities at API and finished product level. If you spot a secondary amine (none are present in the structure of Apixaban), you would have a precursor of a NDSRI. I would specially look for hydrolysis products of those amides, which could lead to secondary amines