Dr. Ashworth published a new paper related to NDSRIs. I can only read the abstract now, and it seems to refer to IQ consortium/EFPIA’s three conditions for NDSRIs manufacturing.
If an N-nitrosamine is formed under these reaction conditions, the information gained can be used as part of the risk assessment and also provides a starting point for the development of a process to synthesize a discrete sample for further testing. Additionally, synthetic and analytical considerations that should be taken into account during preparation of novel N-nitrosamines for use in analytical or toxicological studies are discussed.