Critical Analysis of Drug Product Recalls due to Nitrosamine Impurities

I introduce the paper referring to the recall of pharmaceuticals from the US market due to nitrosamines contamination. The author analyzed more than 1400 recalls such as valsartan, losartan, irbesartan, metformin, ranitidine, and nizatidine in the FDA database. And sartans contributed more than 85% to them. The root causes of these cases and assumed synthetic schemes are also reported.

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