👨‍💻 Determination of nitrite and nitrate in povidone by ion chromatography as part of nitrosamine risk assessment in excipients

[mflorea]

• Detailed nitrite analytical procedures for some excipients are presented in the Online Supplementary Information of the article:
  NDMA analytics in metformin products: Comparison of methods and pitfalls - PubMed
  This includes:
  – “Determination of nitrite in metformin HCl, microcrystalline cellulose, croscarmellose and carmellose using Griess assay followed by HPLC-UV”
  – “Determination of nitrite and nitrate in povidone, magnesium stearate and HPMC 100K using ion chromatography with conductivity detection”

• For HPMC can also check out this thread Nitrite content in hydroxypropyl methylcellulose - Root Causes / Excipients - Nitrosamines Exchange