With so much discussion around Limits and AI calculations, I want to debate for a moment to share information about ‘Duplex Sequencing’. After the recent safety discussion at the Hesi/FDA meeting, I went down a rabbit hole to understand some of the proposed assays and testing that can be used to evaluate the safety or mutagenicity potential in Nitrosamines Impurities.
Duplex Sequencing - I would like to share couple peer-reviewd articles that provide a perspective about duplex sequencing and how this can be used to assess mutaginicity.
