Newly published extract of work from the MUTAMIND project.
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I believe some folks have not dived deep into the findings of this research… I finally had the opportunity to read carefully. Eye opening the outcome!
- NDSRls can form endogenously in the human organism after ingestion of secondary amines
- Enalapril, propranolol, and fluoxetine form NDSRls under conditions mimicking the acidic environment in the stomach
- While the modelling of propranolol was unremarkable, the
highest NA conversion rate observed for N-nitrosoenalapril under gastric conditions resulted in plasma and liver levels exceeding those derived from the CPCA threshold by a factor of about 800 and 400, respectively - The long half-life of fluoxetine suggests a risk of bioaccumulation of its nitrosamine with chronic exposure
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