Formation of Nitroso-Omeprazole

Continuing the discussion from Anybody dealing with possible formation on Nitrosoimidazoles?:

Hi Everyone

Recently, I saw an interesting case in pharmacy. He was a middle-aged man was taking medicines such as Omeprazole, Aspirin, and Nitroglycerin at the same time. I was interested in investigating the interaction of these drug. Finally, I reached a chemical reaction that probably occurs between omeprazole and nitroglycerin and leads to the creation of Nitroso-omeprazole. Figure indicates the detailed mechanism and the pathway of nitroso-omeprazole formation. This reaction has been predicted and simulated using artificial intelligence. Is omeprazole (or other PPIs) at the risk of nitroso-forming?

Best Regards

Saleh Rakhshani