With some much discussion around Nitroso-APIs related to Propranolol, Atenolol, Metoprolol… LOL family. I am some research from Robbiano et al
“Formation of the ,/V-NitrosoDerivatives of Six /?-Adrenergic-blocking Agents and Their Genotoxic Effects in Rat and Human Hepatocytes”
The genotoxic activity of the six nitrosamines was evaluated in primary cultures of both rat and human hepatocytes; DNA fragmentation was measured by the alkaline elution technique and DNA repair synthesis by quantitative autoradiography.