Hexamethyldisilazane (HMDS) can form Nitrosamine Impurity?

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Hi,

Today question:

Hexamethyldisilane (HMDS) can form N-nitrosamine impurity if the synthesis route involves sodium nitrate and acetic acid with acidic pH at high temperature.

Regards,
Dr. Dinkar

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Thanks for your massage. Typo error corrected.

Hexamethyldisilazane (HMDS)` can form N-nitrosamine impurity if the synthesis route involves sodium nitrate and acetic acid with acidic pH at high temperature .

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Dinkar

Hexamethyldisilane
Hexamethyldisilane (HMDS) does not generate nitrosamine impurities. Nitrosamines typically form from secondary or tertiary amines reacting with nitrosating agents, such as nitrites. Since HMDS lacks nitrogen, it cannot directly produce nitrosamines.

However, if other substances in the process contain amines or nitrosating agents, there might be a risk of nitrosamine formation. It’s essential to evaluate the overall reaction environment to assess potential risks comprehensively.

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Thanks a lot for Clarity and Justification.

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For clarity: HMDS = HN[Si(CH3)3]2

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CCDW Oh, I understand now. I had assessed considering Hexamethyldisilane (HMDS) instead of Hexamethyldisilazane. Thanks for the correction.

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The previous assessment was based on Hexamethyldisilane (HMDS) instead of Hexamethyldisilazane (HMDS). Hence, based on your information, favorable conditions are available for the formation of the impurity N,N-bis(trimethylsilyl)nitrous amide. This compound is listed in the literature with CAS No. 1233340-47-0.

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