How to overcome blank interference at NDBA

[mflorea]

Just searching this site, you can see that NDBA contamination from plastic is quite common:

FDA Announcement - Small Molecule Nitrosamines in Infusion Bags

The FDA published a document yesterday around the detection of small molecule nitrosamines, specifically NDBA being detected in infusion bags, potentially from printed overwraps and packaging. august-18-2025-emerging-scientific-and-technical-information-on-leachable-ndba.pdf (205.0 KB) Interesting the CDER are considering an adjustment factor for the lifetime AI limit of four to ten-fold of total nitrosamine exposure. [Nitrosamine Exchange 2025 (7)]

Anyone experienced low level interference/ contamination issues with NDBA during method development?

Posting on behalf of one of our community members.