Hypothetical Nitrosamine in 1-H Indazole / CPCA Approach

Limits of Nitrosamines
1

Hi Team,

Does the CPCA approach apply to a hypothetical nitrosamine in a 1H-indole ring part of a parent molecule?

In such a case, how to calculate AI limits and how to conduct a risk assessment?

Thank you

2

You can find several discussions on the topic on this site.
e.g, AI for en Indole struktur (N-Nitroso melatonin)

3

Thank you! This is such a great forum!

4

Do you have any comments about Nitrosamine formation in 1H-indazole parent compounds?