In situ generation of N-nitrosamine derivatives -publication

I recently came across this publication from Sluggett et all. where it was studying the Artifactual degradation of secondary amine-containing drugs during accelerated stability testing when saturated sodium nitrite solutions are used for humidity control.

While the study was focus on the formation of Nitrosamines during lab stability studies using salt-saturated solutions to produce a particular relative humidity (RH). It was demonstrated the formation of N-nitroso-compounds for Carvedilol, Propranolol. Great read and quite appropriate with all the recent news about LOL products.

Free access: Artifactual degradation of secondary amine-containing drugs during accelerated stability testing when saturated sodium nitrite solutions are used for humidity control - ScienceDirect

1-s2.0-S073170851731676X-main (1).pdf (1.2 MB)

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