Dears,
A very interesting paper is now available around why closely related nitrosamine analogues can have different carcinogenicity
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@Diego_HM, you posted while I was prepping my post… You beat me!
We continue to see more research on the use of quantum mechanics computational models for the determination of acceptable intakes. This time Yu et al. from Pfizer " A Kinetic Model for Assessing Potential Nitrosamine Carcinogenicity"
Abstract:
Understanding the potential carcinogenic potency of nitrosamines is necessary to setting acceptable intake limits. Nitrosamines and the components that can form them are commonly present in food, water, cosmetics, and tobacco. The recent observation of nitrosamines in pharmaceuticals highlighted the need for effective methods to determine acceptable intake limits. Herein, we describe two computational models that utilize properties based upon quantum mechanical calculations in conjunction with mechanistic insights and established data to determine the carcinogenic potency of a variety of common nitrosamines. These models can be applied to experimentally untested nitrosamines to aid in the establishment of acceptable intake limits.
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