Lifetime Cumulative Dose and Less Than Lifetime Approach

Limits of Nitrosamines
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This was published just last week. I don’t have the full version to read yet but will purchase shortly.

Evaluating the Lifetime Cumulative Dose as a Basis for Carcinogenic Potency of Nitrosamines – a Key Tenet Underpinning Less-than-Lifetime Approaches for Establishing Acceptable Intake limits - ScienceDirect

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@David - thank you to you and all your colleagues for this. Something many of us have been waiting for.

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@MarkS, This is an open access article, thanks to HESI and the authors :slight_smile:

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All - this article is available Open Access so everybody should be able to access/download. The corrected version is available as of today (a few incorrect references in the preproof version that was available earlier - please use this version): https://doi.org/10.1016/j.yrtph.2025.105903

This is the first of 2 papers on this topic - we expect the 2nd paper to be published in 2026.

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Thank you @SusanFelter, both for the updated link and the excellent, really helpful work.