Hi!
someone is with the meglumine?
Meglumine (Methylglucamine) is an amino sugar derived from sorbitol.
NITROSO
Hi!
someone is with the meglumine?
Meglumine (Methylglucamine) is an amino sugar derived from sorbitol.
NITROSO
Meglumine can form a nitrosamine-the nitrosomeglumine is commercially available.
Thanks to both of you!
The nitrosamine is commercially available. True!
Regards
Meglumine can nitrosate quite easily and you are right, @IreneNS , it is very difficult to analyze the hydroxy nitrosamines of this kind at low levels because they trail in the reverse phase LC and refuse to elute in many other column packing. especially trying to analyze small amounts is very tough due to trailing. I have faced this during my laboratory days. Try to see if you can derivatize the hydroxy groups in some way to stop the trailing. As they say, necessity is the mother of invention. Other option is as you said, to try some columns that are used traditionally for sugars to see how sensitive they are. Possibly you will be doing a lot of path finding work here .
Thank you very much for the reply.
I haven’t started the task yet, but I’m going to launch into asking lab vendors about the new columns. I have seen that Merck releases its coa with an amide ascentis for example… but I will ask if there are any news in columns (HILIC Sugar etc).
The problem is always the same for me. A client or authority asks the question and they give an absurd response time. There is no method and it looks horrible to set up a parsing method that works (and that we can leave for the batch release routine).
life is hard…
Thank you!! As meglumine is at USP, one day, some of this will be included in their monograph.
So I think it’s interesting to think that it can work as a method… or that marketing people from large suppliers have it on their list of customer needs.
Greetings to all.
Hi Naiffer,
We had success separating meglumine and the n-nitroso meglumine in HILIC mode using Luna Omega Sugar column.
Best,
Rajesh
Thank you for the information!! You make me so happy. Thank you!