N-Nitrosamine impurity of heterocyclic aromatic ring

[Yosukemino]

Nitrosoirbesartan is free from nitrosation in ordinary.

Lupin Pharmaceuticals issues nationwide recall of Irbesartan Tablets

According to the recent studies, the reaction of Irbesartan with nitrous acid produces Irbesartan oxime derivatives, rather than N -Nitrosoirbesartan. Though I’m not sure the details of the recall, it’s helpful to understand nitrosamine risk assessment. [image]