Is N-Nitroso abemacicib reported anywhere in Literature or is it available anywhere. We tried to synthesize by using regular process like sodium nitrite in acidic pH, also we tried Tert butyl nitrile. But, we were not able to synthesize it. Can someone please help to understand the possibility of its formation.
Thank You
Sachin
Dear Sachinb,
this impurity is in the e-list of some impurity vendors but check for its in-stock availability.
Looking at its structure, i think that its synthesis could be quite difficult-due to the resonance with the aromatic rings-but not impossible.
The nice thing with this nitrosamine (if finally you find a ref, standard) is that you could try to ask for the limit of N-nitroso diphenylamine (78000ng/day!!) which have similar structure.
best regards
Christos
2 Likes
Dear Chrischar,
Thank you so much for your response. Yes this impurity is there in list of many vendors, but it is not in stock with anyone i.e never synthesized by any vendor yet.
Thank You
Sachin
Regarding nitroso-abemaciclib, which nitrogen are we referring to? One can imagine at least four potential nitrosamine structures - desethyl-nitroso-abemaciclib, two nitroso-abemaciclib structures resulting from piperazine ring opening, and what we might call the 2-aminopyrimidine nitrogen, which is unlikely to undergo nitrosation due to its low nucleophilicity.
1 Like
this would be the desethyl-
1 Like
dear Naiffer,
i think that the question of Sachinb was for the below molecule
The desethyl-abemaciclib is anticipated to be synthesized quite easily, as it is a typical piperazine-type compound.
kind regards
Christos
2 Likes
Dear Chrischar,
Thank you.
Yes it is the Target nitrosamine.
Regards
Sachin
1 Like
Dear Naiffer,
This could be one of the non nitroso impurity and further a nitroso can be formed on the nitrogen of piperazine Nitrogen.
Thanks
Sachin