N-nitroso clonixin

New Scientific Knowledge & Development
1

I have some issues with this nitrosamine, i think that it converts to clonixin, besause when i infuse, it has the same m/z parents and daughters than clonixin, and when y run the two standards separately, they have the sane retentión time. Anyone have some experiencia working with this nitrosamine? The n-nitrosoclonixin is degradating? Is the first time that this happen to me working with nitrosamines. Thank you!!

Pd: excuse me for my english

2

Clonixin is an ideal candidate for the Fischer-Hepp rearrangement reaction where the N-Nitroso compound can be converted to its C-Nitroso analogue. Having said that, N-Nitroso compounds are typically stable and denitrosation does not happen readily.

Probably, you have to ensure that the standard you are using is well characterized and is indeed N-Nitroso Clonixin.

Hope this helps.