N-Nitroso dially amine estimation by LCMS

Hi,

Can any one give some guidance on developing a method to estimate this NDAA.

not able to achieve enough sensitivity with TQS and not having any literature related to.

Plz share any ideas and suggesiton.

Can you share with the community what have you done so far?

  1. Hard to comment without knowing where you are at the moment

  2. Hence, only generic comments so far: APCI + high API load

  3. Posting this question in “Confirmatory Testing & Analytical Challenges” category would bring more input