N-Nitroso Mefanaminc Acid

Dear all,

We tried the N-Nitroso Mefenamic acid method development by LCMS.But we faced the reproducibility issue. Please anyone develop the method or suggestion give to me for quickly close the issue.

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A novel LC-TQ-MS/MS method for quantifying mefenamic acid-NDSRI (N-nitroso drug substance-related impurity) in mefenamic acid tablet and pediatric suspension dosage forms: a comparative study with a cost-effective white, green, and blue UPLC method - RSC Advances (RSC Publishing)

maybe this helps :slight_smile:

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