N-nitroso-omadacycline mutagenic

[chrischar]

Dear WangLin,

please see the relevant discusion

Why do nitrosamine impurities of omacycline and tigecycline have different AI values?

N-nitroso-tigecycline and N-nitroso-omadacycline have similar structurs,but have different AI:N-nitroso-tigecycline is 1500ng/d，N-nitroso-omadacycline is 26.5ng/d.I don’t have a suitable analysis method，How should I do it?

with regards

Christos