hi all,
I am working on N-Nitroso Phenylephrine and N-Nitroso Phenylephrone impurity quantitation by LC-MS/MS, facing challenges for detection and sensitivity of N-Nitroso Phenylephrine and N-Nitroso Phenylephrone impurity in LC-MS/MS.
Any suggestion or literature that could help related to ionization or sensitivity of these impurity.
Dear @sateesh thank you for sparking this conversation! To help the community dive deeper and offer more targeted insights, could you add a few extra details about the challenge you’re seeing? For example:
- Product or process context – is this related to an API, finished dosage form, excipient, or something else?
- Analytical approach – which techniques or methods have you used so far, and what results (e.g., limits of detection/quantitation) have you observed?
- Regulatory or risk-assessment angle – are you working toward a specific guideline or facing a particular compliance hurdle?
- Sticking points – what part of the investigation is proving most difficult (sample prep, reference materials, data interpretation, etc.)?
The more detail you can share, the easier it will be for fellow members—many of whom have tackled similar issues—to jump in with practical suggestions, references, or even illustrative case studies. Looking forward to the follow-up and a rich discussion!