NitrosAMIDES - Should they be treated the same as Nitrosamines?

New Scientific Knowledge & Development
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The mechanism of activation for N-nitrosAMINES versus N-nitrosAMIDES are discussed, and the fact that they should not be treated the same way

https://www.e-digitaleditions.com/i/1481708-pharmaceutical-technology-october-2022/42?

@trust_user_a @trust_level_1 @trust_user_c

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Hi, @ASrinivasan.

That’s a great article. As you said, we should distinguish the other N-nitroso derivatives from N-nitrosamines. Those compounds have similar features such as structures and high potencies to nitrosamines, but are entirely different. You could clarify them in this article. It’s admirable!! Now we can consider “N-nitroso compounds” in ICH M7 as “N-nitrosamines” and “N-nitroso compounds except for N-nitrosamines”, respectively.

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Hello @ASrinivasan, Thank you for sharing this article. This is insightful. N-Nitrosamides are equally potent and threatening like N-Nitrosamines.

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In some cases they are. But the issue is that they are direct acting mutagens, which means that you dont need to modify the Ames Assay to make sure if they are mutagenic or not. But many nitrosamides are used as anti-cancer drugs. So, we need to be careful in our conclusions.

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