Nitroso Furosemide

Is there anyone working on Nitroso Furosemide?
what could be the possible AI limit based on read across approach?



Dear @Chirag,

The baseline studies retrieved from Lhasa Carcinogenicity Database provided valuable insights into the surrogate potential of N-Nitroso-N-methylaniline. Notably, the Lhasa TD50 value of 0.106 mg/kg/day demonstrated a moderate toxicity level, warranting the adoption of an acceptable intake limit to ensure human safety.

Based on the Lhasa TD50 value, an acceptable intake limit of 106 ng/day was proposed for N-Nitroso-N-methylaniline. This limit ensures a sufficiently low exposure level to mitigate potential adverse effects based on the available toxicological data. It is important to note that this limit should be interpreted within the context of the specific exposure scenarios and risk assessment frameworks applicable to N-Nitroso-N-methylaniline.