Nitroso-Sitagliptin Who/Where/Limit?

[Naiffer_Host]

I believe this is a good case to apply some of the statistical validation that @David presented in a recent publication regarding the potential potency of the Nitrosamine Impurity.

What Makes a Potent Nitrosamine? Statistical Validation of Expert SAR

I’m pleased to be able to announce that our latest paper, looking at applying statistical rigour to the expert SAR feature list that Kevin and I (and others, going all the way back to Lijinsky) have been able to assess subjectively, is finally out. We can now say that steric hindrance has a statistically-significant impact decrease on potency, and metabolically-labile features a statistically-significant increase (w.r.t. a hypothetical featureless nitrosamine). The corollary of this is that we …