the overlap of the mutagenic specimens - here I mean the target genes such as PAC and p53 / in skin cancer patients (melanoma and epithelial skin tumors) with some of the mutant genes (again PAC and p53) affected in the framework of photocarcinogenesis or solar irradiation: is this not one of the serious indirect first-time evidence that proves the photocarcinogenic and mutagenic action of nitrosamines themselves?
Some nitrosamines are directly carcinogenic after irradiation with UVA radiation:
Mochizuki H, Nagazawa Y, Arimoto-Kobayashi S. Genotoxicity and the stability of N-nitrosomorpholine activity following UVA irradiation. Mutat Res Genet Toxicol Environ Mutagen. 2024 Jan;893:503721. doi: 10.1016/j.mrgentox.2023.503721. Epub 2023 Dec 2. PMID: 38272633.
Should the other , nitrosamines found in drugs be tested for photo genotoxicity from now on?
Is the photo genotoxicity dose cumulative?