Peptide Synthesis - Does anyone have experience with potential Nitrosamine impurities coming from solid phase synthesis?

New Scientific Knowledge & Development
1

I am looking for people who have already dealt with peptide systhesis using e.g. Fmoc deprotection and coupling synthesis steps using DIPCDI,HOBt/DMF. Was there any evidence of nitrosamine formation found?

Thank you in advance to whoever helps me on this topic :slight_smile:

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I’m also very interested in this topic and looking forward to someone’s reply.

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