I am doing a risk analysis of nitrosamine impurities in liquid products. In my research, I have not been able to determine the structure or composition of essences and flavors, raw materials involved in the manufacturing process of liquid products. For this reason, it has not been possible to establish a criterion in the risk analysis to determine how the presence of these raw materials influences the formation of nitrosamines.
In view of the above, I would like to know how this subject is covered and how the risk is assessed for these raw materials.
Just for information-you could extend this question to herbal products (natural products in pharmaceutical dosage forms). Some time ago I evaluate something like 50 herbal products for nitrosamine risk…it is small but not non-existent. The biggest problem is identifying alkaloids that have a nitrosatable amine and then trying to establish what concentration they might be in the finished dosage form.