Risk assessment for nitrosated pharmaceuticals: A future perspective

A great article by Schmidtsdorff et all. - The study incorporated a nitrosation assay procedure into high‐resolution supercritical fluid chromatography (SFC)–mass spectrometry screening to test
the potential of direct nitrosation of active pharmaceutical ingredients (APIs)

Link to access: https://onlinelibrary.wiley.com/doi/full/10.1002/ardp.202100435

Archiv der Pharmazie - 2022 - Schmidtsdorff - Risk assessment for nitrosated pharmaceuticals A future perspective in drug.pdf (2.3 MB)


Interesting read and compilation of recall data
Thanks for sharing Naiffer @Naiffer_Host

With so much discussion related to Risk evaluation for Nitroso-API compounds, I want to call your attention to the results from 67 APIs evaluated by Schmidtsdorff from various pharmaceutical classes. ~50% of them form NOCs of which ~20% have not been reported in the literature.