Simple and Practical Method for the Quantitative High-Sensitivity Analysis of N-Nitroso Duloxetine in Duloxetine Drug Products Utilizing LC-MS/MS

Confirmatory Testing & Analytical Challenges
,
1

Dr. Fukuda et al. from Towa Pharmaceutical Co., Ltd published a literature focusing on the testing method for N-nitroso duloxetine. Using LC-MS/MS they analyzed the trace amounts of NDSRIs by methanol extraction.

https://pubs.acs.org/doi/10.1021/acsomega.4c00136

image
image916×574 28.4 KB

You can check the Swissmedic method for Duloxetine. It is similar to Fukuda’s.

3 Likes