如果工艺中有残留的亚硝酸，同时又有伯胺，需要评估亚硝胺风险吗？如何证明伯胺不能生成亚硝胺杂质
@Xuguoqin Nitrosation of primary amines yields primary N-nitrosamines which are unstable at
normal temperatures. They decompose according to the reaction:
Primary aryl amines yield stable aryl diazonium ions. Alkyl diazonium ions, on the other
hand, are not stable in aqueous solution and break down to yield nitrogen and alkyl
carbonium ions which can take part in a multitude of alkylation reactions.
Secondary nitrosamines also arise in the reaction of primary amines with nitrosating
agents although with very low yields.
Risk assessment of your entire chemistry on the reaction vessel is essential to derisk the formation of Nitrosamines.
Please @timothy_curran or @MichaelBurns please add any comments.