Total Nitrosamine Analyzer

Nitrosamines in the News
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Detecting Unexpected Nitrosamine Contamination.pdf (1.2 MB)

Dear colleagues,
New Automated Total Nitrosamine Analyzer solution too much problems associated with nitrosamine impurities.
Nitrites, nitrates and nitrosamines can be detected, as with the TEA glassware system.
Uses the same chemical reaction to release NO.
Molar response for the NO molecules present*
For screening samples for below threshold concentrations (to 1ppb NDMA), identifying those that require further analyses.
Used in the Cosmetics, & Pharmaceutical Industries.
The nitrate molecule is more stable than nitrite/nitrosamine, so does not cleave as well, reducing the LOD for nitrates.
This also fits in with the relative likelihood of nitrosamine formation.
The ATNA system can detect the liberated NO molecules from nitrites, nitrates and
nitrosamines, all of which can be of interest. However, being able to differentiate
between the nitrosamines and nitrites is of importance to understand the current Apparent
Total Nitrosamines Content (ATNC), and for an informed Risk Assessment of the potential
concentration of nitrosamine that could be achieved.
If no nitrites are present, the ATNA system can detect concentrations as low as 1ng/mL (ppb) NDMA.
By tailoring the headspace analysis vial chemistry, Ellutia has been able to remove
concentrations of sodium nitrite up to
10µg/mL (ppm) while still being able to detect NDMA to concentrations as low as 10ng/mL (ppb).
I think its a new revolution in the world of nitrosamine compound analysis.

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Have anybody had real experience with these type of ‘total analyzers’? How about the LOD/LOQ? … Thanks @Hermine401 for brining it up. There has been few post in the past about this technology, but I am curious about the real deployment of it for investigations of Nitrosamines.

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Hi Naiffer and all,
we have sent to Ellutia some samples for testing, some with small nittrosamines and some with NDSRIs.
Its seems that for small nitrosamines, the results were quite accurate even for levels down to 10-20 ppb, but for NDSRIs every case should be checked separately.
We have not finalize all the screening, we are in the second phase.
We would like to highlight two things

  1. Ellutia does not provide sampling analysis, they are selling the machine. They just offered this service to us for a trial, because we ask for this,
  2. The persons in Ellutia knows what they are doing. They are very helpful and willing to answer all of our question in deep.
    best regards
    Christos
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Thanks for sharing your experience.

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