Toxycologist ... not for you!

[Naiffer_Host]

I have to confess: learning toxicology has been a journey for me.

As an analytical chemist, toxicology was not something I had really worked with until nitrosamines came my way. But this field quickly taught me that if we want to understand nitrosamine safety, we also need to understand the toxicology behind it. So many of the limits, safety thresholds, and risk assessment discussions make much more sense when you understand the why behind them.

I am still often amazed by the depth of toxicological discussion I see in the ICH M7 working group. It has pushed me to keep learning, and while I never pretend to be an expert toxicologist, I do believe this is an area all of us in nitrosamines should try to understand better.

Because in the end, this is not just about quality or what your MS system can measure. It is about safety.

I would love for this post to become a repository of helpful resources for non-toxicologists who want to better understand toxicology concepts relevant to nitrosamines.

Dose-response. LD50. Toxicological thresholds. NOGEL. LOGEL. Reference dose. Uncertainty factors. These are all concepts we should become more familiar with.

So please contribute any resources you have found useful or come across that could help others learn and grow in this area.

Enjoy the journey into the fascinating world of nitrosamine toxicology.

[chrischar]

Dear Naiffer,

i am exactly in the same page as you, trying to ‘‘swimming’’ in the toxicology wild sea

what is fascinating me and i am trying to understand deeper, is the benchmark dose approach.

I consider this as a huge challenge and i think that this will be the main tool for setting limits in the NDSRIs.

best regards

Christos

[Hermine4011]

@Naiffer_Host

have to confess: learning toxicology has been a journey for me.

As an analytical chemist, toxicology was not something I had really worked with until nitrosamines came my way. But this field quickly taught me that if we want to understand nitrosamine safety, we also need to understand the toxicology behind it. So many of the limits, safety thresholds, and risk assessment discussions make much more sense when you understand the why behind them.

I am still often amazed by the depth of toxicological discussion I see in the ICH M7 working group. It has pushed me to keep learning, and while I never pretend to be an expert toxicologist, I do believe this is an area all of us in nitrosamines should try to understand better.

Because in the end, this is not just about quality or what your MS system can measure. It is about safety.

I would love for this post to become a repository of helpful resources for non-toxicologists who want to better understand toxicology concepts relevant to nitrosamines.

Dose-response. LD50. Toxicological thresholds. NOGEL. LOGEL. Reference dose. Uncertainty factors. These are all concepts we should become more familiar with.

So please contribute any resources you have found useful or come across that could help others learn and grow in this area.

Enjoy the journey into the fascinating world of nitrosamine toxicology.

Toxicology provides the basis for determining the safety margin…