Visualization of Categorized Compounds by CPCA

Limits of Nitrosamines
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Its good information …Can u share the reference for the same

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Hi @laxman

This might be helpful to you.

A white paper by @ASrinivasan sir.

pharmaceutical-technology-october-2022-43-51.pdf (9.1 MB)

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Hi vinod,

The data I referred to is the same as in the dashboard. Please check it.

Percentage calculation looks different from those in my pie chart.

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Ok Yosukemino Thanks for immediate

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I counted the amounts of nitrosamines with the type of APIs in EMA Appendix.1. The results are as follows;

Nitrosamines which sources are described(=NDSRI): 130
Nitrosamines in API(2ry amine): 72
Nitrosamines in API(3ry amine): 36
Nitrosamines in API(amide): 6
Nitrosamines in API(others): 16

image

APIs were classified by nitrosated nitrogen.
Nitrosamines in API(2ry amine) are generated from direct nitrosation of APIs. Other nitrosamines may be generated from impurities in APIs.

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