Its good information …Can u share the reference for the same
Hi vinod,
The data I referred to is the same as in the dashboard. Please check it.
Percentage calculation looks different from those in my pie chart.
Ok Yosukemino Thanks for immediate
I counted the amounts of nitrosamines with the type of APIs in EMA Appendix.1. The results are as follows;
Nitrosamines which sources are described(=NDSRI): 130
Nitrosamines in API(2ry amine): 72
Nitrosamines in API(3ry amine): 36
Nitrosamines in API(amide): 6
Nitrosamines in API(others): 16
APIs were classified by nitrosated nitrogen.
Nitrosamines in API(2ry amine) are generated from direct nitrosation of APIs. Other nitrosamines may be generated from impurities in APIs.
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I know you posted this over a year ago but I’m hoping you can help explain in a little bit more detail why the α-Hydrogen Score = +1. I understand the 2 and 3 counts of hydrogen atoms on each α-carbon (lowest first) but why is the α-Hydrogen Score(2,3)= +1? Does the α-Hydrogen Score have more to do with the arrangement of the α-carbons (i.e., (2,3))?
Thank you for asking, @erogers3482. Briefly, the α-hydrogen score is a measure of the steric hindrance to α-hydroxylation during the metabolism of nitrosamines by CYP. The α-hydrogen score (2,3) was assigned the lowest score of +1 because steric hindrance is small and α-hydroxylation is thought to proceed relatively easily. Is this the answer you are looking for?
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