Voluntary Recall of lots of ACCUPRIL tablets

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N-nitroso-quinapril

Three days after propranolol was recalled, Pfizer Canada recalled all lots of Accuretic(quinapril hydrochloride and hydrochlorothiazide), which is also used for blood pressure medication, due to N-nitrosamine contamination. [image] N-nitroso-quinapril https://recalls-rappels.canada.ca/en/alert-recall/pfizer-recalls-accuretic-blood-pressure-tablets-due-nitrosamine-impurity Inactive ingredients used in the formulation is as follows; candelilla wax, crospovidone, hydroxypropyl cellulose, hypro…

200+ USP Monograph w/ Tertiary amines

by @ASrinivasan Another victim of the demon, that we call nitrosamine. The recall of Orphenadrine Citrate ER Tablets, though not surprising, is not pleasant. My Ph.D. Advisor, Dr. Richard Loeppky spend most of his life taking about facile nitrosation of some tertiary amines. However, it has always been tough for people to accept it, as it will lead to re-evaluaiton of significant number of drugs. My evaluation of USP monographs show that about 200 or more of the monographed products are tertia…