What is CPCA Score for “N-nitroso of 3-Amino-1,2,4-triazole".
The potency categorisation approach (CPCA) does not apply to N-nitrosamines where the N-nitroso group is attached to a nitrogen within a hetero aromatic ring (e.g., nitrosated indole).
ref.to:
Carcinogenic Potency Categorisation Approach for Nnitrosamines
Can you please provide a bit more context with the question? Thanks
This nitrosamine impurity is coming from “3 Amino 1,2,4-Triazole” and it does not follow CPCA rules to assign an exact category. My question is how we assign CPCA category.
Thanks, Dinkar. I think this post should help you with the limit definition and justification. The same framework was used to develop CPCA.
Thank you so much, sir, for your insightful feedback. It is really beneficial to our pharmaceutical society as well as to myself.