Which Molecule Is Involved in the Nitrosation Reaction of Pharmaceuticals: NO or NO 2 ? -Pub

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Nomura et al. from Towa Pharmaceutical evaluated the respective impacts of NO₂ and NO on the nitrosation of pharmaceuticals. This study is a follow-up to their previous work, which investigated the use of chemical filters to reduce atmospheric nitrogen oxides during pharmaceutical manufacturing. According to their experimental results, NO₂, rather than NO, had a significant impact on the nitrosation reaction. These findings provide further evidence supporting the effectiveness of removing NO₂ with chemical filters as a strategy to mitigate nitrosamine formation.

https://pubs.acs.org/doi/10.1021/acs.oprd.6c00108

ABSTRACT:
We have previously clearly identified atmospheric nitrogen oxides (NOx) as a key factor in nitrosamine contamination in pharmaceuticals. To implement more appropriate countermeasures, the nitrosation potential of nitrogen monoxide (NO) and nitrogen dioxide (NO2)─the primary components of NOx─was evaluated using short-term and long-term gas flow model experiments. The results revealed that NO2 is required for the nitrosation reaction to occur.

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Very interesting publication. Even some experiments designs for small and large scales evaluation of NOx filter efficiency are shared.

One more paper that highlights, yes NOx is an issue in unit operations with high drying gas volume flow. Our experience is the same, this is a real root cause.

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Good practical focus on NOx as a ubiquitous pollutant nowadays.

NO in air is known to oxidize readily to NO2. This may explain the background nitrosation levels in “absence of NO2” but also raises a question if NO2 free environments are possible with NO or NOx in aerobic conditions.

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Thanks for sharing. This is very helpful for both manufacturing and analytical procedures to control the influence of environmental NO2.

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