This week ANAMDED (National Regulatory Agency from Chile) announced the voluntary recall of all Atomoxetine DP due presence of NDSRIs
We can use NNK as point of departure for structure-activity-relationship (SAR) /read-across approach same as Nitroso Duloxetine and Nitroso Fluoxetine
Are you suggesting 4-(Methylnitrosoamino)-1-(3-pyridinyl)-1-butanone as surrogate?
Lhasa Carcinogenicity database: Gold TD50 = 99.9 ng/day ?
Yes. EMA has published limit 100 ng/day for both Nitroso Duloxetine and Nitroso Fluoxetine based on NNK.