Measuring Nitrites in headspace

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Maybe this post can help as a starting point!

API seem to form N-nitrosamines upon oxidation (e.g. air) and without the presence of nitrosonium ions

In a recent public post, Moritz raised the following concern: I am currently looking at a very unusual problem, and am wondering whether a group member might be able to help: Some API seem to form N-nitrosamines upon oxidation (e.g. air) and without the presence of nitrosonium ions. For example Tolazamide was reported to form NHM upon oxidation. Is anyone aware of any regulatory guidance on such problems or has anybody experience whether such an oxidation can be supressed effectively by anti…