N-Nitroso Metformin Chemistry

[chrischar]

Hi Dileep,
i think that the following thread could answer to your questions

N-Nitroso Metformin

Dear team, I seek your insights and guidance regarding N-Nitroso Metformin. According to one of our API suppliers, the theoretical possibility of the NDSRI has been evaluated based on the API structure. However, the supplier faced challenges in synthesizing this impurity, deeming it a difficult task, and the CPCA approach was found to be inapplicable. This has left us in a state of confusion on how to address this issue in the finished product. While searching on Google and various impurity sup…

hope it helps,
thanks