🤷‍♂️ FAQ: How do I calculate the CPCA of my Nitrosamine Impurity?

CPCA Calculation

Example of How to calculate CPCA

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Visualization of categorized compounds

Calculation of α-hydrogen score (Illustration of @David’s description)

About the exception of CPCA (Nitrosamides and others)

About the exception of CPCA (Nitrosamines where the N-nitroso group is within an aromatic ring (e.g., nitrosated indole))

An example of deactivating feature (a 6-membered ring fused with another ring)

Difference of guidance between EMA and FDA